2013-07-10 

环球医学   

   

近日，汤森路透（Thomson Reuters ）旗下的 ScienceWatch 网站，以论文的引用次数为依据，盘点了2012年度最热门科学家以及最热门研究论文。值得一提的是，今年总共有6名华人学者上榜，分别为中科院金属研究所研究员成会明博士、武汉理工大学的余家国教授、中科院化学研究所的李永舫博士，以及英国布鲁奈尔大学的王子栋教授、复旦大学的丁莉博士、王俊博士。

 

2012科研热点主要集中在四个方面：1上帝粒子；2基因组学与生物医学；3材料研究；4大数据研究。

 

2012年度最热门科学人物主要依据"高引用率论文"的数量确定。在入围榜单中，基因组学领域研究人员占了相当大的一部分，其中最炙手可热的人物是华盛顿大学医学院的 Richard Wilson。Wilson在2010～2012年期间总共有15篇高引用率的文章。他领导的研究小组参与了千人基因组计划，并在《自然》（Nature）杂志上发表了题为"A Map of Human Genome Variation from Population-scale Sequencing"的文章。

 

大名鼎鼎的 Broad 研究院院长Eric Lander也榜上有名。他也是"A Map of Human Genome Variation from Population-scale Sequencing"的文章的作者之一，此外还有12篇高引用率的文章，包括卵巢癌、血液癌和脑癌等方面的基因组研究。

 

deCODE Genetics总裁 Kari Stefansson 卷土重来，在上一份报告跌出榜单之后今年又一跃成为最热门的科学家。他在2012年有13篇文章，聚焦帕金森氏病、精神分裂症和阿尔茨海默病的基因组研究。

 

除了这些赫赫有名的人物，今年也有一些新面孔上榜。华盛顿大学 Richard Wilson 团队还有3人上榜，分别是 Elaine Mardis、丁莉 和 Robert Fulton。他们参与了千人基因组计划，另外还有2篇文章跻身热门文章。密歇根大学的生物统计学家Goncalo Abecasis 除参与千人基因组计划外，近日也发表了一系列文章，报道GWAS 研究糖尿病、体重指数（BMI）和心血管疾病风险的结果。

 

据介绍，早前毕业于复旦大学的丁莉博士成功领导了肺腺癌的基因组学研究，并确定了导致肺癌的关键基因和通路。她还与其他同事一起分析了一位白血病患者的肿瘤和皮肤基因组，这也是第一个完全测序并进行分析的癌症基因组。

 

最热门研究论文排名：

 

1、G. Aad, et al., "Combined search for the Standard Model Higgs boson using up to 4.9fb(-1) of pp collision data at root s=7 TeV with the ATLAS detector at the LHC," Phys. Lett. B, 710(1): 49-66, 29 March 2012.

 

2、S. Chatrchyan, et al., "Combined results of searches for the Standard Model Higgs boson in pp collisions at root s=7 TeV," Phys. Lett. B, 710(1): 26-48, 29 March 2012.

 

3、F.P. An, et al., "Observation of electron-antineutrino disappearance at Daya Bay," Phys. Rev. Lett., 108(17): No. 171803, 23 April 2012.

 

4、M. Gerlinger, et al., "Intratumor heterogeneity and branched evolution revealed by multiregion sequencing," New Engl. J. Med., 366(10): 883-92, 8 March 2012.

 

5、J.R. Lemen, et al., "The Atmospheric Imaging Assembly (AIA) on the Solar Dynamics Observatory (SDO)," Solar Physics, 275(1-2): 17-40, January 2012.

 

6、J.R. Lemen, et al., "The Atmospheric Imaging Assembly (AIA) on the Solar Dynamics Observatory (SDO)," Solar Physics, 275(1-2): 17-40, January 2012.

 

7、Y.M. Sun, et al., "Solution-processed small-molecule solar cells with 6.7% efficiency," Nature Materials, 11(1): 44-8, January 2012.

 

8、J.K. Ahn, et al., "Observation of reactor electron antineutrinos disappearance in the RENO experiment," Phys. Rev. Lett., 108(19): 11 May 2012.

 

9、C.J.L. Murray, et al., "Global malaria mortality between 1980 and 2010: a systematic analysis," Lancet, 379(9814): 413-31, 4 February 2012.

 

10、J.A. Sosman, et al., "Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib," New Engl. J. Med., 366(8): 707-14, 23 February 2012.

 

11、G. Aad, et al., "Search for squarks and gluinos using final states with jets and missing transverse momentum with the ATLAS detector in root s=7 TeV proton-proton collisions," Phys. Lett. B, 710(1): 67-85, 29 March 2012.

 

12、J.L. Mega, et al., "Rivaroxaban in patients with a recent acute coronary syndrome," New Engl. J. Med., 366(1): 9-19, 5 January 2012.

 

13、C.L. Ogden, et al., "Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010," JAMA, 307(5): 483-90, 1 February 2012.

 

14、Y. Abe, et al., "Indication of reactor (nu) over-bar(e) disappearance in the Double Chooz Experiment," Phys. Rev. Lett., 108(13): No. 131801, 28 March 2012.

 

15、K.M. Flegal, et al., "Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010," JAMA, 307(5): 491-7, 1 February 2012.

 

16、J. Baselga, et al., "Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer," New Engl. J. Med., 366(2): 109-19, 12 January 2012.

 

17、V. Mourik, et al., "Signatures of Majorana fermions in hybrid superconductor-semiconductor nanowire devices," Science, 336(6084): 1003-7, 25 May 2012.

 

18、S. Chatrchyan, et al., "Search for the Standard Model Higgs boson decaying into two photons in pp collisions at root s=7 TeV," Phys. Lett. B, 710(3): 403-25, 12 April 2012.

 

19、C.E. Small, et al., "High-efficiency inverted dithienogermolethienopyrrolodione-based polymer solar cells," Nature Photonics," 6(2):115-20, February 2012.

 

20、G. Aad, et al., "Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC," Phys. Lett. B, 716(1): 1-29, 17 September 2012.

 

21、A.S. Lok, et al., "Preliminary study of two antiviral agents for hepatitis C genotype 1," New Engl. J. Med., 366(3): 216-24, 19 January 2012.

 

22、A. Arbey, et al., "Implications of a 125 GeV Higgs for supersymmetric models," Phys. Lett. B, 708(1-2): 162-9, 14 February 2012.

 

23、.L. Nolan, et al., "Fermi Large Area Telescope second source catalog," Astrophys. J. Suppl Ser., 199(2): No. 31, April 2012.

 

24、O. Zuk, et al., "The mystery of missing heritability: Genetic interactions create phantom heritability," PNAS, 109(4): 1193-8, 24 January 2012.

 

25、D.A.R. Barkhouse, et al., "Device characteristics of a 10.1% hydrazineprocessed Cu2ZnSn(Se,S)4 solar cell," Prog. Photovoltaics, 20(1): 6-11, January 2012.

 

26、N. Suzuki, et al., "The Hubble Space Telescope Cluster Supernova Survey. V. Improving the dark-energy constraints above z > 1 and building an earlytype-hosted supernova sample," Astrophys. J., 746(1): No. 85, 10 February 2012.

 

27、B.F. Haynes, et al., "Immune-correlates analysis of an HIV-1 vaccine efficacy trial," New Engl. J. Med., 366(14): 1275-86, 5 April 2012.

 

28、L. Ding, et al., "Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing," Nature, 481(7382): 506-10, 26 January 2012.

 

29、S. Chatrchyan, et al., "Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC," Phys. Lett. B, 716(1): 30-61, 17 September 2012.

 

30、F. Su, et al., "RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors," New Engl. J. Med., 366(3): 207-15, 19 January 2012

 

31、S.K. Kodali, et al., "Two-year outcomes after transcatheter or surgical aortic-valve replacement," New Engl. J. Med., 366(18): 1686-95, 3 May 2012.

 

32、M. Carena, et al., "A 125 GeV SM-like Higgs in the MSSM and the γ γ rate,"J. High Energy Physics, 3: No 014, March 2012.

 

33、J. Baselga, et al., "Everolimus in postmenopausal hormone-receptorpositive advanced breast cancer," New Engl. J Med., 366(6): 520-9, 9 February 2012.

 

34、. Bostrom, et al., "A PGC1-alpha-dependent myokine that drives brownfat-like development of white fat and thermogenesis," Nature, 481(7382):463, 26 January 2012.

 

35、R.R. Makkar, et al., "Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomized, phase 1 trial," Lancet, 379(9819): 895-904, 10 March 2012.

 

36、.R. Schauer, et al., "Bariatric surgery versus intensive medical therapy in obese patients with diabetes," New Engl. J. Med., 366(17): 1567-76, 26 April 2012.

 

37、S.J. Park, et al., "Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases," Cell, 148(3): 421-33, 3 February 2012.

 

38、J.S. Healey, et al., "Subclinical atrial fibrillation and the risk of stroke," New Engl. J. Med., 366(2): 120-9, 12 January 2012.

 

39、J.H. Zhang, et al., "The genetic basis of early T-cell precursor acute lymphoblastic leukaemia," Nature, 481(7380): 157-63, 12 January 2012.

 

40、L.J. Hall, et al., "A natural SUSY Higgs near 125 GeV," J. High Energy Physics, 4: No. 131, April 2012.

 

41G. Mingrone, et al., "Bariatric surgery versus conventional medical therapy for Type 2 diabetes," New Engl. J. Med., 366(17): 1577-85, 26 April 2012.

 

42、D.H. Barouch, et al., "Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys," Nature, 482(7383): 89, 2 February 2012.

 

43、L. Sjostrom, et al., "Bariatric surgery and long-term cardiovascular events," JAMA, 307(1): 56-65, 4 January 2012.

 

44、B.J. O'Roak, et al., "Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations," Nature, 485(7397): 246, 10 May 2012.

 

45、S. Heinemeyer, O. Stal, G. Weiglein, "Interpreting the LHC Higgs search results in the MSSM," Phys. Lett. B, 710(1): 201-6, 29 March 2012.

 

46、G. Aad, et al., "Search for the Standard Model Higgs boson in the diphoton decay channel with 4.9 fb(-1) of pp collision data at root s=7 TeV with ATLAS," Phys. Rev. Lett., 108(11): No. 111803, 13 March 2012.

 

47、. Tricoci, et al., "Thrombin-receptor antagonist vorapaxar in acute coronary syndromes," New Engl. J. Med., 366(1): 20-33, 5 January 2012.

 

48、A. Azatov, R. Contino, J. Galloway, "Model-independent bounds on a light Higgs," J. High Energy Physics, 4: No. 127, April 2012.

 

49、.E. Cramer, et al., "ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models," Science, 335(6075): 1503-6, 23 March 2012.

 

50、L. Britnell, et al., "Field-effect tunneling transistor based on vertical graphene heterostructures," Science, 335(6071): 947-50, 24 February 2012.

 

51、J. Schwartzentruber, et al., "Driver mutations in histone H3.3 and chromatin remodeling genes in paediatric glioblastoma," Nature, 482(7384): 226, 9 February 2012.