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<DIV style="mso-char-wrap: 1; mso-kinsoku-overflow: 1; mso-line-spacing: '100 50 0'"><STRONG><FONT color=#0000ff><FONT style="FONT-FAMILY: 楷体_GB2312; FONT-SIZE: 18px"> 肠道病毒71型(EV71)</FONT><SPAN style="FONT-FAMILY: 仿宋_GB2312; COLOR: blue; FONT-SIZE: 24pt; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'"><FONT style="FONT-FAMILY: 楷体_GB2312; FONT-SIZE: 18px">属于小RNA病毒科,肠道病毒属,A组肠道病毒。 </FONT></SPAN></FONT></STRONG>
<DIV class=O v:shape="_x0000_s1026"><STRONG><FONT color=#0000ff><FONT style="FONT-FAMILY: 楷体_GB2312"><FONT style="FONT-SIZE: 18px"><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'; mso-fareast-language: ZH-CN" lang=EN-US> 1972年EV71在美国被首次确认,1974年Schmidt等首次发表从美国</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">加利福尼亚州20例具有中枢神经系统症状患者(1969~1973年)中</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">分离到EV71。</SPAN></FONT></FONT><SPAN style="FONT-FAMILY: 仿宋_GB2312; COLOR: blue; FONT-SIZE: 24pt; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'"><FONT style="FONT-FAMILY: 楷体_GB2312; FONT-SIZE: 18px">随后,世界上众多国家都有EV71流行的报道。</FONT></SPAN><FONT style="FONT-FAMILY: 楷体_GB2312"><FONT style="FONT-SIZE: 18px"><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'; mso-fareast-language: ZH-CN" lang=EN-US>EV71感染可引起HFMD、疱疹性咽峡炎、无菌性脑炎、脑膜炎和脊</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">髓灰质炎样麻痹,但更多情况下是产生隐性感染。同脊灰病毒相</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">似,EV71对脊髓前角细胞具有一定的组织嗜性,是最常见的引起</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">急性迟缓性麻痹(acute flaccid paralysis,AFP)的非脊灰肠</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">道病毒(non-polio enterovirus,NPEV),</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'; mso-fareast-language: ZH-CN" lang=EN-US>EV71潜伏期一般为3-</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'; mso-fareast-language: ZH-CN" lang=EN-US>7天。 </SPAN></FONT></FONT><FONT style="FONT-FAMILY: 楷体_GB2312"><FONT style="FONT-SIZE: 18px"><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">感染EV71后,患者发病1~2周内可自咽部排出病毒,从粪便中排毒</SPAN><SPAN style="FONT-FAMILY: ; COLOR: blue; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'">可持续至发病后3~5周。 </SPAN></FONT></FONT></FONT></STRONG>
<DIV style="mso-char-wrap: 1; mso-kinsoku-overflow: 1"><SPAN style="FONT-FAMILY: 仿宋_GB2312; COLOR: blue; FONT-SIZE: 24pt; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'"><FONT style="FONT-FAMILY: 楷体_GB2312; FONT-SIZE: 18px" color=#0000ff><STRONG>疱疹液中含大量病毒,疱疹破溃后病毒排出。</STRONG></FONT></SPAN><SPAN style="FONT-FAMILY: 仿宋_GB2312; COLOR: blue; FONT-SIZE: 24pt; mso-ascii-font-family: 仿宋_GB2312; mso-fareast-font-family: 仿宋_GB2312; mso-hansi-font-family: 'Times New Roman'"><FONT style="FONT-FAMILY: 楷体_GB2312"><FONT style="FONT-SIZE: 18px"><STRONG><FONT color=#0000ff><SPAN style="FONT-FAMILY: ; mso-spacerun: yes"> </SPAN> </FONT></STRONG></FONT></FONT></SPAN></DIV>
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