如何在肿瘤高分SCI期刊发表研究论文的体会

2011年第一天查pubmed查到International Journal of Cancer在线发表NIH一个课题组的肿瘤论文

http://www.ncbi.nlm.nih.gov/pubmed/21140450

Int J Cancer. 2010 Dec 7. [Epub ahead of print]

GCF2 interacts with dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines.

Ohtsuka H, Oikawa M, Kyohei A, Rikiyama T, Motoi F, Katayose Y, Unno M, Johnson AC.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

前言部分接连引用了我作为通讯作者最近发表的两篇论文

The role of PCP signaling is critical in multiple embryonic processes

including embryo morphogenesis29. It is noteworthy that embryonic development shares many similarities with cancer development and conserved signaling pathways involved in embryogenesis including Wnt, Hedgehog, and Notch are dysregulated in tumorigenesis. Thus, it comes as no surprise that Wnt-PCP pathway is implicated in cancer cell adhesion, migration, or invasion. Characterization of a variety of PCP components, including Wnt, Fzd, Dvl, and RhoA, has shown their involvement in cancer cell invasion or metastasis30.

29. Wang Y, Steinbeisser H. Molecular basis of morphogenesis during vertebrate gastrulation. Cell Mol Life Sci 2009;66:2263-73.

30. Wang Y. Wnt/Planar cell polarity signaling: a new paradigm for cancer therapy. Mol Cancer Ther 2009;8:2103-9.

经典Wnt通路在发育和肿瘤中的作用早已得到大家共识，在自己一定研究工作的基础上我重点针对非经典Wnt通路这一大家尚未重视的领域提出假设和新思路，2009年发表于AACR旗下杂志MCT（Wang Y. Wnt/Planar cell polarity signaling: a new paradigm for cancer therapy. Mol Cancer Ther 2009;8:2103-9. ）, 希望开拓本领域的新方向，该综述很快被AACR举办的Cancer Reviews Online收录，George C. Prendergast （Editor-in-Chief）评论如下: A review from Yingqun Wang introduces the idea that disruptionsof planar cell polarity during tumorigenesis occur as a resultof disruptions in Wnt signaling (Molecular Cancer Therapeutics,August issue; ref. 2). ...不少学者Email索求全文，表达他们对本文的极大兴趣。此外，我收到此领域知名专家(素不相识)的Email评论如下: Dear Dr. Wang, I just wanted to drop you a note to express how much I enjoyed your minireview in MCT on PCP and Cancer. Kudos!

Senior Investigator

Head, Developmental Signal Transduction Section

Laboratory of Cell and Developmental Signaling

National Cancer Institute-Frederick

Frederick, MD 21702

该综述发表至今已被下列文章引用，表明我的思路和假设得到越来越多实验和理论验证，本文开头的NIH课题组的最新研究结果就是明证。

肿瘤和胚胎发育之间的相似性为我们提供了一个新思路来研究肿瘤，考虑到同一基因在不同物种之间结构和功能上的高度保守性，从发育生物学的独特角度来研究癌基因和抗癌基因，利用医院的临床优势，收集肿瘤临床标本，验证在模式生物上所得到的研究结果是否适用于临床标本，实现in vitro → in vivo (animal model) → in vivo (human) 的研究周期，我相信这一设想有望为肿瘤防治开辟新思路，帮助大家在高分肿瘤杂志发表文章，取得新成果。

Articles citing this article (up to 8 MAR 2011, 大约1年半时间被他引19次)

GC-binding factor 2 interacts with dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines. International Journal of Cancer 2011 DOI: 10.1002/ijc.25837
Promoter methylation of Wnt antagonists DKK1 and SFRP1 are associated with opposing tumor subtypes in a large cohort of colorectal cancers. Carcinogenesis 2011 DOI: 10.1093/carcin/bgr020
Physiological inhibitors of Wnt signaling. European Journal of Haematology DOI: 10.1111/j.1600-0609.2011.01592.x
Drug discovery approaches to target wnt signaling in cancer stem cells. Oncotarget. 2010 Nov;1(7):563-77.
Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells. Current Pharmaceutical Biotechnology 2011 12:160-170
Global Profiling and Molecular Characterization of Alternative Splicing Events Misregulated in Lung Cancer. Mol Cell Biol. January 1, 2011 31:138-150
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: Implications in cancer and embryogenesis. J Biol Chem. November 12, 2010 285:35740-35749
Gene expression profiling reveals new aspects of PIK3CA mutation in eralpha-positive breast cancer: Major implication of the Wnt signaling pathway. PLoS ONE 2010 5 (12), art. no. e15647
Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras-Mutated Colorectal Cancer. Molecular Cancer Therapeutics December 1, 2010 9:3351-3362
Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. J Cell Sci. September 15, 2010 123:3157-3165
Unifying Insights into Cancer Cell Signaling: Hedgehog, Cell Polarity, Complement, and CTLA-4 Polymorphisms. CRO Content January 1, 2009 2009:17-18
The relationship between early embryo development and tumourigenesis. Journal of Cellular and Molecular Medicine. 2010 14:2697-2701
How a lipid mediates tumour suppression. FEBS Journal. 2010 277:4837-4848
Striking the target in Wnt-y conditions: Intervening in Wnt signaling during cancer progression. Biochemical Pharmacology. 2010 80:702-711
Wnt signalling in implantation, decidualisation and placental differentiation – Review. Placenta 2010 31:839-847
Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns. Laboratory Investigation 2010 90:1247-1258
Governing the Invasive Trophoblast: Current Aspects on Intra- and Extracellular Regulation. American Journal of Reproductive Immunology. 2010 63:492-505
Proteomic profiling of MDCK plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition. Mol Cell Proteomics. 2011 Feb;10(2):M110.001131.
Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer. Breast Cancer Res Treat. 2010 Jul 3. [Epub ahead of print]王颖群博士原创，转载请注明出处