Age-related differences in the clinical characteristics of systemic lupus erythematosus in children. Zhu J, Wu F, Huang X. SourceDivision of Pediatric Rheumatology, Children's Hospital Affiliated Capital Institute of Pediatrics, No.2 Yabao Road, Chaoyang District, Beijing, 100020, China. Abstract The objective of this study was to determine how the clinical presentation of systemic lupus erythematosus in pediatric varied with the age of onset of the disease. We reviewed the charts of a total of 88 Chinese pediatric patients (pSLE) diagnosed and admitted first time to our hospitals between 2005 and 2008. Patients were divided into 3 groups, depending on the age at diagnosis: preschool (1-6 years), school age (7-11 years), and adolescent groups (12-18 years). Among the three groups, we compared the sex ratio, disease duration at diagnosis, symptoms at the onset of the disease, clinical manifestations, laboratory examinations, SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) 2000, and SLICC/ACR SDI (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index for Systemic Lupus Erythematosus). Most pediatric patients were in the adolescent group (47.7%), while the disease duration at diagnosis was shortest in preschool-age patients (0.65 ± 0.5 months). The most common symptoms at the onset of pSLE were fever, rash, arthritis, and seizures. Hematologic system and neuropsychiatric system were damaged commonly. The preschool-age patients had the shortest disease duration at diagnosis, the highest incidence of neuropsychiatric system involvement, and the poorest prognosis of all the age groups, especially the boys. Patients in adolescence had the peak incidence of pediatric SLE and high disease activity, begins to acquire some of the adult characteristics. School-age is a transition stage between other stages. PMID:22228466[PubMed - as supplied by publisher] LinkOut - more resourcesFull Text SourcesSpringerSwets Information Services 首都儿科研究所附属儿童医院的一项研究显示，儿童系统性红斑狼疮（pSLE）的临床特征存在年龄差异。研究在线发表于2012年1月7日《风湿病国际》（Rheumatol Int）。 　　该研究目的是确定儿童系统性红斑狼疮临床表现是怎样随发病年龄变化的。研究人员共收集了2005年到2008年间诊断并首次到本院的88例SLE患儿病例资料，根据诊断时年龄将其分为三组：学龄前组（1-6岁）、学龄期组（7-11岁）、青少年组（12-18岁）。研究人员比较三组的性别比、病程、发作症状、临床表现、实验室检查、系统性红斑狼疮病活动指数（SLEDAI2000）和系统性红斑狼疮损伤指数（SLICC/ACR SDI）。 　　结果显示，47.7%患儿在青少年组，而学龄前患儿确诊前病程最短，平均0.65个月。SLE患儿最常见的症状是发热、皮疹、关节炎和发作。血液系统和神经精神系统常常受损。学龄前患儿确诊前病程最短、神经系统受累率最高；三个年龄组患儿预后都差，尤其是男孩。青少年期是儿童SLE发病的高峰，疾病活动性高，并且青少年患者开始出现成人SLE的一些特征。学龄期是其他阶段的一个过渡阶段。